| 庄 嫚,李秀云,张珊珊,李晓伟,张丁冉.四磨汤联合马来酸曲美布汀治疗肝郁气滞型消化性溃疡疗效分析[J].中国烧伤创疡杂志,2025,(4):316~323. |
| DOI： |
| 中文关键词: 四磨汤 马来酸曲美布汀 肝郁气滞 消化性溃疡 中医证候 幽门螺杆菌 |
| 英文关键词:Simo decoction Trimebutine maleate Liver depression and Qi stagnation Peptic ulcer TCM
syndrome Helicobacter pylori |
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| 中文摘要: |
| 【摘要】 目的 分析四磨汤联合马来酸曲美布汀治疗肝郁气滞型消化性溃疡的临床疗效。 方法 选取 2021 年 2 月至 2024 年 2 月郑州市第三人民医院收治的 100 例肝郁气滞型消化性溃疡患者为研究对象, 按照随机数表法将其分为试验组 (50 例) 与对照组 (50 例)。 试验组患者在四联疗法治疗基础上加用四磨汤与马来酸曲美布汀, 对照组患者仅进行四联疗法治疗, 对比两组患者细胞因子水平、H + -K + -ATP 酶活性、中医证候积分、幽门螺杆菌根除率及临床疗效。 结果 治疗2 周后, 试验组患者前列腺素 E2 (PGE2)、碱性成纤维细胞生长因子 (bFGF)、血管内皮细胞生长因子 (VEGF) 水平均高于对照组 (t = 20.271、6.165、6.143, P 均<0.001), H + -K + -ATP 酶活性低于对照组 (t = 4.353, P<0.001); 治疗 4 周后, 试验组患者中医证候各主次证评分及总分均低于对照组 ( t = 5.322、5.909、3.851、4.282、3.265、4.000、4.081、22.420, P< 0.001、P< 0.001、P< 0.001、P< 0.001、P = 0.002、P<0.001、P<0.001、P<0.001), 幽门螺杆菌根除率高于对照组 ( χ 2 = 3.981, P = 0.046), 临床疗效优于对照组 (Z= -2.396, P= 0.017)。 结论 四磨汤联合马来酸曲美布汀治疗肝郁气滞型消化性溃疡, 可通过提高细胞因子水平、幽门螺杆菌根除率及降低 H + -K + -ATP 酶活性促进溃疡愈合, 改善临床症状, 疗效显著。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the clinical efficacy of Simo decoction combined with trimebutine maleate in treating peptic ulcer of liver depression and Qi stagnation type. Methods 100 patients with peptic ulcer of liver depression and Qi stagnation type admitted to Zhengzhou Third People’s Hospital from February 2021 to February 2024 were enrolled as research subjects, and divided, using the random number table, into the experimental group (n = 50) and the control group ( n = 50). Patients in the experimental group were treated with Simo decoction and trimebutine maleate based on the standard quadruple therapy, while patients in the control group received the quadruple therapy alone. Cytokine levels, H + -K + -ATPase activity, TCM syndrome scores, Helicobacter pylori eradication rate, and clinical efficacy were compared between the two groups. Results After 2 weeks of treatment, the levels of prostaglandin E2 ( PGE2 ), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) of patients in the experimental group were higher than the control group (t = 20.271, 6.165 and 6.143, all P< 0.001). H + -K + -ATPase activity was lower in the experimental group ( t = 4.353, P<0.001). After 4 weeks of treatment, the scores of all primary and secondary TCM syndrome symptoms and the total score of patients in the experimental group were lower than the control group ( t = 5.322, 5.909, 3.851, 4.282, 3.265, 4.000, 4.081 and 22.420, P<0.001, P<0.001, P<0.001, P<0.001, P = 0.002, P<0.001, P<0.001, P< 0.001). The Helicobacter pylori eradication rate was higher (χ 2 = 3.981, P= 0.046), and the clinical efficacy was better in the experimental group (Z = - 2.396, P = 0.017). Conclusion The combination of Simo decoction and trimebutine maleate in the treatment of peptic ulcer of liver depression and Qi stagnation type can increase cytokine levels and Helicobacter pylori eradication rate, reduce H + -K + -ATPase activity, promote ulcer healing, and improve clinical symptoms, and the clinical efficacy is definite. |
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