• 血清NGAL、NT-proBNP检测对烧伤患者脓毒症早期诊断的临床效能评估
  • Evaluation of the clinical efficacy of serum NGAL and NT-proBNP tests for the early diagnosis of sepsis in burn patients
  • DOI:
    中文关键词:  烧伤,脓毒症,感染指标
    英文关键词:burns, sepsis, infection indicators
    基金项目:
    作者单位邮编
    魏永琪 南京医科大学 223200
    杨卫玺* 南京医科大学 223300
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    中文摘要:
          目 的:研究中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、N末端脑钠素肽(NT-proBNP)在烧伤脓毒症中的临床应用价值。方 法:本研究回顾性分析了2023年1月—2025年1月南京医科大学附属淮安市第一人民医院收治的63例烧伤面积大于20%的烧伤患者的临床资料,依据是否合并脓毒症分为脓毒症组和非脓毒症组。比较两组患者的一般情况、烧伤情况及预后,并比较两组烧伤后第1、3天WBC,N,PLT,MPV,PCT,NGAL,NT- proBNP的水平。有显著性差异的指标再进行受试者工作特征(ROC)曲线的绘制,评估上述指标在大面积烧伤患者早期脓毒症诊断中的价值。结 果: MPV、NGAL、PCT及NT-proBNP对烧伤脓毒症的早期诊断具有更高的临床价值。
    英文摘要:
          Objective:To study the clinical application value of NGAL and NT-proBNP in burn sepsis. Methods:This study retrospectively analyzed the clinical data of 63 burn patients with burn area greater than 20% admitted to the First People's Hospital of Huai'an City, affiliated to Nanjing Medical University, from January 2023 to January 2025, and divided them into sepsis and non-sepsis groups based on whether they were combined with sepsis or not. The general conditions, burns and prognosis of patients in the two groups were compared, and the levels of WBC, N, PLT, MPV, PCT, NGAL, and NT- proBNP were compared between the two groups on the 1st and 3rd day after burns. Indicators with significant differences were then subjected to the drawing of work characteristics (ROC) curves to assess the value of the above indicators in the early diagnosis of sepsis in patients with extensive burns. Results: MPV, NGAL, PCT and NT-proBNP have higher clinical value in the early diagnosis of burn sepsis.