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创伤后感染创面应用抗生素骨水泥疗效分析
Clinical Efficacy of Antibiotic Bone Cement in Treating Post⁃traumatic Infected Wounds

叶远,萧秋平,刘虎浪,韦兵,夏孟红.创伤后感染创面应用抗生素骨水泥疗效分析[J].中国烧伤创疡杂志,2025,(3):214~217.

DOI：

英文关键词:Trauma Infection Debridement Antibiotic bone cement Wound

基金项目:

作者	单位
叶远	408400 重庆, 重庆医科大学附属南川区人民医院创伤科
萧秋平
刘虎浪
韦兵
夏孟红

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中文摘要:

【摘要】目的分析创伤后感染创面应用抗生素骨水泥治疗的临床疗效。方法选取2022年3月至 2023年3月重庆医科大学附属南川区人民医院收治的164例创伤后创面感染患者作为研究对象, 按照不同治疗方法将其分为研究组 (82例) 和对照组 (82例), 研究组患者局部创面于彻底清创后应用抗生素骨水泥治疗,对照组患者局部创面于彻底清创后应用负压封闭引流治疗, 对比两组患者血清白细胞介素-6 ( IL-6)、肿瘤坏死因子-α (TNF-α)等炎症因子水平以及临床疗效与创面愈合时间。结果治疗 3 周后, 研究组患者血清 IL-6、TNF-α 水平均明显低于对照组 (t = 13.860、16.094, P均<0.001), 临床疗效明显优于对照组 (Z = -2.343, P = 0.019); 研究组患者创面愈合时间明显短于对照组 ( t=4.852, P<0.001)。结论应用抗生素骨水泥治疗创伤后感染创面, 能够有效减轻创面炎症反应, 加快创面愈合, 临床效果显著。

英文摘要:

【Abstract】 Objective To analyze the clinical efficacy of antibiotic bone cement in treating post-traumatic infected wounds. Methods 164 patients with post-traumatic infected wounds admitted to The People’s Hospital of Nanchuan Affiliated to Chongqing Medical University from March 2022 to March 2023 were enrolled as research subjects and divided into the study group (n = 82) and the control group (n = 82) based on different treating methods. The local wounds of patients in the study group were managed with antibiotic bone cement after thorough debridement, while the local wounds of patients in the control group were managed with vacuum sealing drainage after thorough debridement. The serum levels of inflammatory factors, including interleukin-6 ( IL-6) and tumor necrosis factor-α (TNF-α), clinical efficacy, and wound healing time were compared between the two groups. Results After 3 weeks of treatment, serum IL-6 and TNF-α levels of patients in the study group were significantly lower than those in the control group ( t = 13.860 and 16.094, both P< 0.001). The clinical efficacy of patients in the study group was significantly better than that of the control group (Z = - 2.343, P = 0.019). The wound healing time of patients in the study group was significantly shorter than that in the control group ( t = 4.852, P<0.001). Conclusion The application of antibiotic bone cement in treating post-traumatic infected wounds can effectively reduce wound inflammatory response, accelerate wound healing, presenting remarkable clinical efficacy.