• 血清胆红素、纤维蛋白原、D-二聚体在2型糖尿病患者发生糖尿病足中的预测价值
  • The Predictive Value of Serum Bilirubin,Fibrinogen and D-dimer in Patients with Type 2 Diabetic Foot
  • 邵琳琳.血清胆红素、纤维蛋白原、D-二聚体在2型糖尿病患者发生糖尿病足中的预测价值[J].中国烧伤创疡杂志,2021,(2):95~98.
    DOI:
    中文关键词:  胆红素  纤维蛋白原  D-二聚体  2型糖尿病  糖尿病足  预测价值
    英文关键词:Bilirubin  Fibrinogen  D-dimer  Type 2 diabetes  Diabetic foot  Predictive value
    基金项目:
    作者单位
    邵琳琳 汝州市中医院内分泌科 
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    中文摘要:
          目的 分析血清胆红素、纤维蛋白原、D-二聚体在2型糖尿病患者发生糖尿病足中的预测价值。方法 根据纳入与排除标准选取2018年1月至2020年1月汝州市中医院收治的96例糖尿病足患者和105例2型糖尿病患者作为研究对象,并分别将其设为糖尿病足组与糖尿病组,另外选取同期于汝州市中医院接受健康体检的80名健康体检者作为健康对照组,对比3组研究对象血清胆红素、纤维蛋白原、D-二聚体水平,分析三者与糖尿病足的相关性及其在2型糖尿病患者发生糖尿病足中的预测价值。结果 糖尿病足组与糖尿病组患者血清总胆红素、直接胆红素及间接胆红素水平均明显低于健康对照组,且尤以糖尿病足组患者水平最低(F=36.150、4.448、26.660,P<0.001、P =0.013、P<0.001);纤维蛋白原、D-二聚体水平均明显高于健康对照组,且尤以糖尿病足组患者水平最高(F=60.420、260.000,P均<0.001);Spearman相关系数分析结果显示,血清总胆红素、直接胆红素及间接胆红素水平与糖尿病足呈显著负相关性(r=-0.152、-0.163、-0.147,P=0.011、0.006、0.014),纤维蛋白原、D-二聚体水平与糖尿病足呈显著正相关性(r=0.172、0.203,P=0.004、0.001);受试者工作特征(ROC)曲线分析结果显示,血清胆红素、纤维蛋白原、D-二聚体联合检测预测糖尿病足的敏感度为93.4%,特异度为92.9%。结论 血清胆红素、纤维蛋白原、D-二聚体与糖尿病足的发生密切相关,联合检测三者水平对预测2型糖尿病患者的糖尿病足发生风险具有重要意义,临床应用价值较高。
    英文摘要:
          【Abstract】Objective To analyze the predictive value of serum bilirubin,fibrinogen and D-dimer in patients with type 2 diabetic foot. Methods Ninety-six patients with diabetic foot and 105 patients with type 2 diabetes,admitted to the Ruzhou Hospital of Traditional Chinese Medicine from January 2018 to January 2020 were selected,according to the inclusion and exclusion criteria,as the research subjects and were set as a diabetic foot group and a diabetic group,respectively. Meanwhile,80 healthy subjects who received physical examination at the Ruzhou Hospital of Traditional Chinese Medicine were chosen and set as the healthy control group. The levels of serum bilirubin,fibrinogen,and D-dimer of patients in the three groups were compared. The correlation between the three factors and diabetic foot and their predictive values in the occurrence of diabetic foot in patients with type 2 diabetes were analyzed. Results The levels of serum total bilirubin,direct bilirubin and indirect bilirubin in the diabetic foot group and the diabetic group were all significantly lower than that in the healthy control group,with the lowest in the diabetic foot group (F=36.150,4.448,26.660,P <0.001,P = 0.013,P <0.001); the levels of fibrinogen and D-dimer of patients in the first two groups were significantly higher than that in the healthy control group,with the highest in the diabetic foot group (F=60.420,260.000,all P< 0.001). Spearman correlation coefficient showed that there was a significant negative correlation between the levels of serum total bilirubin,direct bilirubin and indirect bilirubin,and diabetic foot (r=-0.152,-0.163,-0.147,P=0.011 0.006,0.014),there was significantly positive correlation between the levels of fibrinogen and D-dimer,and diabetic foot (r=0.172,0.203,P=0.004,0.001),and the receiver operating characteristic (ROC) curve analysis showed that,the sensitivity of the combined detection of serum bilirubin,fibrinogen,and D-dimer in predicting diabetic foot was 93.4%,and the specificity was 92.9%. Conclusion The levels of serum bilirubin,fibrinogen,and D-dimer are closely related to the occurrence of diabetic foot. Combined detection of the levels of the three is of great significance in predicting the occurrence of diabetic foot in patients with type 2 diabetes,presenting a high value of clinical application.