• 湿润烧伤膏对Wagner 2~3级糖尿病足患者神经修复的作用
  • Effect of MEBO on Nerve Repair in Patients with Wagner Grade 2-3 Diabetic Foot
  • 李 平,魏翠艳.湿润烧伤膏对Wagner 2~3级糖尿病足患者神经修复的作用[J].中国烧伤创疡杂志,2021,(2):91~94.
    DOI:
    中文关键词:  湿润烧伤膏  重组牛碱性成纤维细胞生长因子凝胶  糖尿病足  神经  修复  氧化应激
    英文关键词:MEBO  Recombinant bovine basic fibroblast growth factor gel  Diabetic foot  Nerve  Repair  Oxidative stress
    基金项目:
    作者单位
    李 平 永城市人民医院 
    魏翠艳  
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    中文摘要:
          目的 对比分析湿润烧伤膏与外用重组牛碱性成纤维细胞生长因子凝胶对Wagner 2~3级糖尿病足患者的神经修复作用。方法 选取2017年9月至2019年9月永城市人民医院收治的156例Wagner 2~3级糖尿病足患者作为研究对象,并按照随机数表法将其随机分为研究组与对照组,每组78例。研究组患者局部创面于外科清创后行湿润烧伤膏换药治疗,对照组患者局部创面于外科清创后行外用重组牛碱性成纤维细胞生长因子凝胶治疗,对比观察两组患者神经病变评分、腓总神经传导速度、氧化应激水平变化情况及临床疗效。结果 治疗14、28 d时,两组患者密歇根神经病变筛选法(MNSI)评分及总症状评分法(TSS)评分均降低,腓总神经运动传导速度(MCV)及感觉传导速度(SCV)均升高,且两组间无明显差异(14 d:t=0.358、2.747、0.498、0.546,P=0.721、0.457、0.619、0.586;28 d:t=0.495、0.432、0.340、0.476,P=0.621、0.667、0.735、0.635);超氧化物歧化酶(SOD)水平均明显升高、丙二醛(MDA)水平均明显降低,且研究组患者SOD水平明显高于对照组(t=2.082、2.581,P=0.039、0.011),MDA水平明显低于对照组(t=2.608、2.294,P=0.010、0.023)。治疗28 d时,研究组患者临床疗效与对照组无明显差异(Z=-0.675,P=0.500)。结论 湿润烧伤膏可有效促进糖尿病足患者的神经修复,进而加快创面愈合,且抑制机体氧化应激反应可能是其部分作用机制。
    英文摘要:
          【Abstract】Objective To compare and analyze the nerve repair effect of MEBO and externally-used recombinant bovine basic fibroblast growth factor (rbFGF)) gel on patients with Wagner grade 2-3 diabetic foot. Methods 156 patients with Wagner grade 2-3 diabetic foot,admitted to The People’s Hospital of Yongcheng from September 2017 to September 2019,were selected as the research subjects to be divided,according to the random number table,into a study group and a control group,78 cases each group. After surgical debridement,the patients in the study group were treated with MEBO,while the patients in the control group with rbFGF gel. The score of neuropathy,conduction velocity of common peroneal nerve,changes in oxidative stress level and clinical efficacy in the two groups was compared and observed. Results On day 14 and day 28 of treatment,the Michigan Neuropathy Screening Instrument(MNSI) scores and Total Symptom Score (TSS) all decreased in the two groups,and motor conduction velocity (MCV) and sensory conduction velocity (SCV) of common peroneal nerve all elevated,and the differences between the two groups were not statistically significant (day 14: t=0.358,2.747,0.498 and 0.546,P=0.721,0.457,0.619 and 0.586; day 28: t=0.495,0.432,0.340 and 0.476,P=0.621,0.667,0.735 and 0.635). The levels of superoxide dismutase (SOD) in the both groups increased substantially while the levels of malondialdehyde (MDA) declined significantly. Moreover,the SOD levels in the study group were significantly higher than that in the control group (t=2.082,2.581,P=0.039,0.011),the MDA levels were significantly lower than that in the control group (t=2.608,2.294,P=0.010,0.023). On day 28 of treatment,there was no significant difference in terms of clinical efficacy between the two groups (Z=-0.675,P=0.500). Conclusion MEBO can help repair the nerves of patients with diabetic foot,thereby speeding up wound healing process. Inhibiting oxidative stress response in such patients may be part of its mechanism of action.