• 坦索罗辛与双氯芬酸钠在输尿管软镜碎石术中的临床作用对比
  • Comparison of the Clinical Effect of Tamsulosin and Diclofenac Sodium in Flexible Ureteroscopic Lithotripsy
  • 李慎谟.坦索罗辛与双氯芬酸钠在输尿管软镜碎石术中的临床作用对比[J].中国烧伤创疡杂志,2020,(4):279~282.
    DOI:
    中文关键词:  坦索罗辛  双氯芬酸钠  输尿管软镜  钬激光碎石  输尿管结石
    英文关键词:Tamsulosin  Diclofenac sodium  Flexible ureteroscope  Holmium laser lithotripsy  Ureteral stone
    基金项目:
    作者单位
    李慎谟 郑州人民医院泌尿外科 
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    中文摘要:
          目的 对比分析输尿管软镜钬激光碎石术前应用坦索罗辛与双氯芬酸钠的临床作用。方法 选取2017年1月至2019年1月郑州人民医院泌尿外科收治的90例拟行输尿管软镜钬激光碎石术治疗的输尿管上段结石患者作为研究对象,并按照入院顺序单双号分为观察组(45例)和对照组(45例),观察组患者于输尿管软镜钬激光碎石术前口服盐酸坦索罗辛缓释胶囊,对照组患者于输尿管软镜钬激光碎石术前口服双氯芬酸钠缓释胶囊,对比两组患者手术时间、术中出血量、结石清除率以及术中输尿管黏膜损伤、输尿管穿孔、输尿管内出血等并发症发生率。结果 观察组患者手术时间及术中出血量与对照组均无明显差异(t=0.725、0.621,P=0.470、0.536),但结石清除率明显高于对照组(χ2=5.294,P=0.021),并发症发生率明显低于对照组(χ2=6.154,P=0.013)。结论 与双氯芬酸钠相比,输尿管软镜钬激光碎石术前应用坦索罗辛能够有效预防术中输尿管黏膜损伤等并发的发生,提高结石清除率,且药物不良反应轻微,对手术治疗无影响,安全性较高,值得临床推广应用。
    英文摘要:
          Objective To compare and analyze the clinical effect of oral administration of tamsulosin and diclofe? nac sodium in flexible ureteroscopic lithotripsy. Methods 90 patients suffering from upper ureteral stone treated with uret? eroscopic holmium laser lithotripsy, admitted to Department of Urology, Zhengzhou People’s Hospital from January 2017 to January 2019, were selected as research subjects and divided, according to the odevity of admission number, into an obser?vation group (45 cases) and a control group (45 cases). Patients in the observation group took tamsulosin hydrochloride sustained?release capsules orally before ureteroscopic holmium laser lithotripsy, while patients in the control group took diclofenac sodium sustained?release capsules orally before ureteroscopic holmium laser lithotripsy. The surgery time, blood loss during surgery, stone clearance rate and the incidence of such complications as the injury, perforation and bleeding of ureteral mucosa were compared between the two groups. Results No significant difference was observed in surgery time and blood loss during surgery between the two groups (t=0.725, 0.621, P=0.470, 0.536), the stone clearance rate in the observation group was significantly higher than that in the control group (χ2=5.294, P=0.021) and the incidence of complications in the observation group was significantly lower than that in the control group (χ2=6.154, P=0.013). Conclusion Compared with the application of diclofenac sodium, the application of tamsulosin before ureteroscopic holmium laser lithotripsy can prevent the occurrence of complications such as the injury of ureteral mucosa and improve stone clearance rate. It has mild adverse reactions and is very safe to be used in surgery. Therefore, it derserves to be promoted in clinical practice.