• 烧伤再生医学与疗法创面治疗原则及机理阐述
  • Mechanism and Principle of Topical Wound Management of Burn Regenerative Medicine and Therapy
  • 陈永翀,李青,张泰安.烧伤再生医学与疗法创面治疗原则及机理阐述[J].中国烧伤创疡杂志,2014,(1):1~14.
    DOI:
    中文关键词:  烧伤再生医学与疗法  治疗  机理  潜能再生细胞  干细胞  原位再生
    英文关键词:Burns Regenerative Medicine and Therapy  Treatment  Mechanism  Potential Regenerative Cell (PRC)  Stem cell  In situ regeneration
    基金项目:
    作者单位
    陈永翀 北京市丰台区南苑医院烧伤创疡科 
    李青  
    张泰安  
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    中文摘要:
          目的 探讨? 了解烧伤再生医学与疗法的创面治疗机理, 阐述坚持再生医学与疗法创面治疗原则的重要性, 规范创面换药操作程序? 方法 通过实验室细胞学观察研究和模拟对照研究的方法, 阐述和论证在实施湿润暴露疗法? 湿润半暴露疗法和湿润包扎疗法时, 坚持烧伤再生医学与疗法创面治疗原则的依据和重要性?结果 水? 消毒液? 抗生素等均会直接损伤人体组织细胞, 不宜应用于创面; 湿润烧伤膏(MEBO) 药纱在半暴露疗法和包扎疗法中起到较好的稳定MEBO框架剂型? 吸附? 引流? 保持创面立体式生理湿润环境的作用, 能够有效延长和维持MEBO对创面的治疗时间, 疗效基本等同于湿润暴露疗法? 结论 在烧伤再生医学与疗法的临床应用中, 无论是采用湿润暴露疗法? 湿润半暴露疗法和湿润包扎疗法治疗创面, 只要严格遵守创面治疗原则和规范的换药操作程序, 就能够实现较好的皮肤组织器官原位再生效果?
    英文摘要:
          Objective: To discuss and explore the mechanism of wound management of Burns Regenerative Medicine and Therapy, demonstrate the importance of following its principle of wound management, and standardize the procedure of wound dressing change. Methods: Lab cytological observation study and simulation control study were used to elaborate and demonstrate the evidence and importance of insisting on the principle of wound management of Burns Regenerative Medicine and Therapy when this therapy was performed by moist exposed, semi-exposed or bandaged dressing method. Results: Water, antiseptics, antibiotics and the like all directly damaged human tissue cells and thus were unfavorable for the wound management; Moist Exposed Burn Ointment (MEBO) impregnated oil-dressing used in semi-exposed or bandaged dressing method exerted effects of stabilizing frame-work MEBO dosage form, absorption, smooth drainage and maintenance of a three-dimensional physiologically moist environment on the wound, obviously prolonging and sustaining the effect duration of MEBO on the wound with efficacy almost equal to moist exposed dressing method. Conclusion: In clinical application of Burns Regenerative Medicine and Therapy, no matter what dressing method is used, i.e. moist exposed, semi-exposed or bandaged dressing method, optimal results of in situ regeneration of skin tissue and organ could be achieved as long as principle and standard procedure of wound management are followed strictly.